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MRC Prion Unit
From fundamental research to prevention and cure

2007 Publications

A general model of prion strains and their pathogenicity
Collinge J, Clarke A.
  Science 2007; 318(5852):930-6.

Proteomic Profiling of Plasma in Huntington's Disease Reveals Neuroinflammatory Activation and Biomarker Candidates
Dalrymple A, Wild EJ, Joubert R, Sathasivam K, Björkqvist M, Petersén A, Jackson GS, Isaacs JD, Kristiansen M, Bates GP, Leavitt BR, Keir G, Ward M, Tabrizi SJ.
Journal of Proteomic Research 2007; 6(7):2833-40.

beta-PrP form of human prion protein stimulates production of monoclonal antibodies to epitope 91-110 that recognise native PrP(Sc)
Khalili-Shirazi A, Kaisar M, Mallinson G, Jones S, Bhelt D, Fraser C, Clarke A, Hawke SH, Jackson GS, Collinge J.
Biochimica et Biophysica Acta 2007; 1774:1438-1450.

A novel presenilin 1 deletion (p.L166del) associated with early onset familial Alzheimer's disease
Knight WD, Kennedy J, Mead S, Rossor MN, Beck J, Collinge J, Mummery C.
European Journal of Neurology 2007; 14(7):829-31.

Targeting cellular prion protein reverses early cognitive deficits and neurophysiological dysfunction in prion-infected mice
Kovacs T, Beck JA, Papp MI, Lantos PL, Aranyi Z, Szirmai IG, Farsang M, Stuke A, Csillik A, Collinge J

Journal of Neurology Neurosurgery and Psychiatry 2007;78(3):321-3.

Disease-Associated Prion Protein Oligomers Inhibit the 26S Proteasome
Kristiansen M, Deriziotis P, Dimcheff DE, Jackson GS, Ovaa H, Naumann H, Clarke AR, van Leeuwen FW, Menendez-Benito V, Dantuma NP, Portis JL, Collinge J, Tabrizi SJ.
Mol.Cell 2007;26(2):175-88.

Neuroimaging findings in human prion disease
Macfarlane RG, Wroe SJ, Collinge J, Yousry TA, Jager R.
Journal of Neurology Neurosurgery and Psychiatry 2007;78(7):664-70.

Targeting cellular prion protein reverses early cognitive deficits and neurophysiological dysfunction in prion-infected mice
Mallucci GR, White MD, Farmer M, Dickinson A, Khatun H, Powell AD, Brandner S, Jefferys JG, Collinge J.
Neuron 2007;53(3):325-35.

Inherited prion disease with 5-OPRI: phenotype modification by repeat length and codon 129
Mead S, Webb TE, Campbell TA, Beck J, Linehan JM, Rutherfoord S, Joiner S, Wadsworth JD, Heckmann J, Wroe S, Doey L, King A, Collinge J.
Neurology 2007;69(8):730-8.

Creutzfeldt-Jakob disease, prion protein gene codon 129VV, and a novel PrPSc type in a young British woman.
Mead S, Joiner S, Desbruslais M, Beck J, O'Donoghue M, Stevens J, Rossor M, Lantos P, Wadsworth J, Collinge J.

Arch Neurol. 2007 Dec;64(12):1780-4.

ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B)
Parkinson N, Ince PG, Smith MO, Highley R, Skibinski G, Andersen PM, Morrison KE, Pall HS, Hardiman O, Collinge J, Shaw PJ, Fisher EM.
Neurology 2007;67:1074-7.

Inhibition of Proteinase K Activity by Copper(II) Ions
Stone LA, Jackson GS, Collinge J, Wadsworth JD, Clarke AR.
Biochemistry 2007;46(1):245-52.

CHMP2B C-truncating mutations in frontotemporal lobar degeneration are assoociated with an aberrant endosomal phenotype in vitro
Van der Zee J, Urwin H, Engelborghs S, Bruyland M, Vandenberghe R, Dermaut  BDPT, Peeters K, Santens P, De Deyn PP, Fisher EM, Collinge J, Isaacs AM, Van Broeckhoven C.
Hum.Mol.Gen. 2007;E-Pub.

Prion infectivity in variant Creutzfeldt-Jakob disease rectum
Wadsworth JD, Joiner S, Fox K, Linehan JM, Desbruslais M, Brandner S, Asante EA, Collinge J.
Gut 2007;56(1):90-4.

Update on human prion disease
Wadsworth JD, Collinge J.
Biochimica et Biophysica Acta 2007;1772(6):598-609.

Molecular diagnosis of human prion disease. In: Hill AF, editor.
Wadsworth J, Powell C, Beck J, Joiner S, Linehan J, Brandner S et al. Prion Proteins: Methods in Molecular Biology. 2007.

Update on vCJD prevalence based on tonsil screening. WHO guidelines on tissue infectivity distribution in transmissible spongiform encephalopathies
Wadsworth J P28. 2006.  WHO press, World Health Organisation, Geneva, Switzerland.

Prions. In: Mahy M, Van Regenmortel M
Wadsworth J, Collinge J. Prions Encyclopedia of Virology. 3rd ed. Elsevier, Oxford, UK; 2007

The differential diagnosis of chorea
Collinge J, Clarke A.
Science 2007; 318(5852):930-6.