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MRC Prion Unit
From fundamental research to prevention and cure
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2018 Publications

Super-Resolution Imaging of Amyloid Structures over Extended Times Using Transient Binding of Single Thioflavin T Molecules. Spehar K, Ding T, Sun Y, Kedia N, Lu J, Nahass GR, Lew MD, Bieschke J. 2018, Chembiochem. 19, 1944-1948.

Evaluating the causality of novel sequence variants in the prion protein gene by example.
Mok TH, Koriath C, Jaunmuktane Z, Campbell T, Joiner S, Wadsworth JDF, Hosszu LLP, Brandner S, Parvez A, Truelsen TC, Lund EL, Saha R,  Collinge J, Mead S
Neurobiol Aging. 2018 May 15. pii: S0197-4580(18)30167-2. doi: 10.1016/j.neurobiolaging.2018.05.011. [Epub ahead of print]

Reply to: Intrinsic Toxicity of Antibodies to the Globular Domain of the Prion Protein
Purro SA, Mead S, Khalili-Shirazi A, Nicoll AJ, Collinge J.
Biol Psychiatry. 2018 Apr 12. pii: S0006-3223(18)31437-9. doi: 10.1016/j.biopsych.2018.04.002. [Epub ahead of print]

Experimental sheep BSE prions generate the vCJD phenotype when serially passaged in transgenic mice expressing human prion protein 
Joiner, S., Asante, EA, Linehan, J.M., Brock, L., Brandner, S., Bellworthy, S.J., Simmons, M.M., Hope, J., Collinge, J. and Wadsworth, J.D.F. (2018) J. Neurol. Sci. 386, 4-11.

Neurofilament light chain and tau concentrations are markedly increased in the serum of patients with sporadic Creutzfeldt-Jakob disease, and tau correlates with rate of disease progression. 
Thompson AGB, Luk C, Heslegrave AJ, Zetterberg H, Mead SH, Collinge J, Jackson GS J Neurol Neurosurg Psychiatry. 2018 Feb 27.

Prion Protein as a Toxic Acceptor of Amyloid-β Oligomers.
Purro SA, Nicoll AJ, Collinge J.
Biol Psychiatry.2018 Feb 15;83(4):358-368. doi: 10.1016/j.biopsych.2017.11.020.
Epub 2017 Nov 21.

The language disorder of prion disease is characteristic of a dynamic aphasia and is rarely an isolated clinical feature.
Caine D, Nihat A, Crabb P, Rudge P, Cipolotti L, Collinge J, Mead S.
PLoS One. 2018 Jan 5;13(1):e0190818. doi: 10.1371/journal.pone.0190818. eCollection 2018.